Disabled people are prohibited from traveling alone because so many train stations in the UK do not have step-free access.
Analysis by the Leonard Cheshire charity found that 40% of the 2,560 stations in the country could not be used by some disabled passengers.
It is said that the lack of clear information about accessibility makes it difficult to plan trips and that there are problems regulating roads to get people between platforms and trains.
Reports claim this is "prohibiting disabled people from traveling independently".
Previous research by Leonard Cheshire stated that more than a third (35%) of people working in working age had problems using trains last year as a result of their disability.
Charity chief executive Neil Heslop said: "Poor public transportation forces disabled people to lose the daily activities that others take for granted, from employment opportunities to social events.
"Disabled people cannot continue to risk their lives. Train operators must make their absolute priority to ensure that their train stations have step-free access, so that all their customers can travel according to their choice."
At present passengers with disabilities who need help must contact the train operator by telephone or through a long online process. Details are then printed and given to station staff.
But delays and cancellations can make this information redundant, leaving some people without the help they need.
To try to fight this, a smartphone application is being developed that will make it easier for people with inability to order and change the terms of assistance for train travel.
The passenger assistance application is scheduled to be launched throughout the UK in the fall of next year.