Barcelona ensure they will reach the Champions League knockout stage as Group B winners with a win at PSV.
The Spanish side have qualified for the last 16 but sealed the top spot with a smart second attack by Lionel Messi and Gerard Pique.
Pique stabbed into the bottom corner in what looked like a planned move from Messi's sweeping delivery, after Argentina fired home through the crowd.
Luuk de Jong scored a late entertainer for PSV, who lost a number of opportunities.
After the match, Pique said that the preparation for his goal was "practiced", but Messi then suggested there was an element of luck involved, because he denied the defense's claims.
"It's not trained," Messi said. "It is a lie.
"It's a bad free kick, Pique is there and the goal is just luck."
The Dutch side hit the Barca goal four times before finally finding the net, with five times the European champions repeatedly being hit behind.
This led to a tormenting end to the match for Barca, and Denzel Dumfries had a strong injury-time time shout rejected after Clement Lenglet appeared to catch him in the box with an awkward challenge.
With one game remaining, Barca lead second-placed Tottenham on six points, with Spurs leading Inter Milan on goal difference,
Their last match in the group stage was at home to Mauricio Pochettino's side on Tuesday, December 11, when Inter hosted bottom side PSV.