The lack of an FLU vaccine has caused thousands of people over 65 years to not get an injection.
Patients have been turned away repeatedly by doctors and chemists.
And even though fresh supplies have to be available next week, there is concern many parents won't bother returning.
Deficiencies have been noted in many areas including Bristol, Kent, Devon, West Sussex, Essex, Derbyshire, Middlesbrough and Liverpool.
Sources told the Daily Mail that the latest vaccine, called Fluad, is more effective but cannot be ordered more than usual. Some doctors claim there is a delay in getting official advice on how to use it.
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John Kell, of the Patients Association, said: "This presents a risk that is very worrying for patient safety and can put NHS services under further pressure."
NHS figures released yesterday showed 45.2 percent of over-65s had vaccines so far compared to 61.9 percent during the same period last year.
The NHS UK says jab "will be available to everyone in due course when the flu season usually starts in December".
Bristol pharmacist John Billing said he refused up to 15 patients a day.
He said: "This came to the point where some patients said" well, I will forget this year & # 39; "