& # 39; Shaking feet & # 39; to reverse osteoporosis



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Chewy bone tissue has osteoporosiscopyright image
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Osteoporosis occurs in the paralyzed limb, causing bone loss and fractures

Researchers at Strathclyde University will test radical new ways to combat osteoporosis bone disease.

Volunteers will make their legs paralyzed with small amounts in an effort to reverse the missing bone.

The "nanokicking" technique can have far-reaching implications for treating spinal cord injury.

The study, which according to British Science Minister Chris Skidmore shows "big promise", is rooted in the search for gravitational waves.

Nano vibration

If you have ever broken a bone you will know it is unpleasant to say the least. But do you know what is happening when it's cured?

Everything is centered on your stem cells, part of your body's repair mechanism.

At the resting location, adult stem cells are given a signal to start making new bones. The signal is in the form of vibration at a very small distance and frequency and is very precise.

An interdisciplinary research team succeeded in doing the same thing in Scottish laboratories, taking human stem cells and vibrating precisely on nanoscale measurements based on billions of meters.

Therefore nano is in "nanokicking".

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The team previously managed to convert stem cells into bone fragments in the laboratory in 2013

The idea is to convert stem cells into pieces of bone that are suitable for re-grafting into donors. Because the cells come from the same patient, there will be no possibility of being rejected.

In 2013, BBC Scotland reported the technique was successful in the laboratory.

There is also hope that someday it might be applied directly to the patient's body. That day is near.

A team led by Prof. Stuart Reid has won £ 350,000 from the British Council of Science and Technology Facilities (STFC) to spend two years applying nanoscale vibrations to patients with spinal cord injuries.

Fifteen volunteers treated in the National Spinal Injury Unit at Queen Elizabeth University Hospital in Glasgow will make their paralyzed legs vibrate in an effort to stop and reverse their osteoporosis.

When the limbs are paralyzed, the lack of daily stress and the strain used causes an "osteoporosis disuse" where the bones weaken and become more likely to break.

copyright image
Strathclyde University

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The Prof Stuart Reid team now has the funds to apply nanoscale vibrations to patients with spinal cord injuries

Successful trials will generate more hope. An estimated three million people in England suffer from osteoporosis, which causes around 500,000 broken bones every year.

The process already exists to persuade stem cells to become bones but this is expensive and complex.

"Nanokicking" provides the prospect of a simple solution that can prevent bone loss and cure it.

This technique can also be used in space.

Astronauts at the International Space Station lose bone density because gravity is low in orbit.

So the British Space Agency continues to be informed about developments with the National Osteoporosis Society.

Increase the scale

Prof. Reid first specialized in making very accurate measurements needed to express it as part of the search for gravitational waves. The same accuracy that now governs the distance and frequency of the vibrating stem cells.

He is still a member of the LIGO scientific collaboration, a major international effort that proves Einstein's century-old prediction that gravitational waves will be found.

Now leading an interdisciplinary team that straddles biomedical techniques and spacetime, he said positive results from trials will lead to improved projects to get more benefits from people with spinal cord injuries.

Prof. Matt Dalby, co-inventor of the technology & # 39; nanokicking & # 39;, was involved in original stem cell research and was part of the research team on this latest project, together with Dr. John Riddell, who led the project's biological investigation. , both from Glasgow University.

Back in 2013 he told BBC Scotland about his hope that patients, not only cells in petri dishes, would one day tremble to grow new bones for themselves.

But he warned that "some terrible math" would be involved. They can be close to solving problems.

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