The realization is explained in detail in a work published on January 16, write findă.ro.
Organoid is a three-dimensional increase in structure in stem cells that mimics an organ and can be used to study the properties of the organ in laboratory conditions.
"The ability to make human blood vessels as organoid in stem cells is revolutionary," said Josef Penninger of the University of British Columbia, one of the study authors.
"Every organ in our body is connected to the circulatory system. This innovation can enable researchers to uncover the causes and develop treatments for various vascular diseases, Alzheimer's disease, heart disease, wound healing, cancer and, of course, diabetes," he added.
Diabetes affects around 420 million people worldwide. Many symptoms are the result of changes in blood vessels, which cause circulation problems and tissue oxygenation.
Although spread, very little is known about changes in blood vessels arising from diabetes. This limitation has slowed the creation of drugs.
To overcome this problem, Penninger and his colleagues developed a revolutionary model: three-dimensional organoid from a human blood vessel that grows in a laboratory. They can grow using stem cells that mimic the structure and function of real blood vessels.
"We can use it to study disease"
When scientists transplanted organoids into mice, they found that they had become perfectly functioning blood vessels such as arteries and capillaries. This discovery shows that it is possible not only to make organoid blood vessels from human stem cells, but also to increase them in the circulatory systems of other animals.
"What's exciting about this work is that we can make real blood stem cells from stem cells," said Reiner Wimmer, the first author of the study. "Our organisms resemble striking capillaries, even at the molecular level, and now we can use them to study blood vessel-related diseases directly on human tissue," added the researcher.
One characteristic of diabetes is that blood vessels have abnormal thickening of the basement membrane. As a result, the delivery of oxygen and nutrients to cells and tissues becomes difficult, resulting in many health problems.
The researchers exposed organoids to the "diabetes" environment in the petri dish. "Strangely, I can observe the expansion of the basement membrane in organoids from blood vessels," Wimmer said. "The typical thickening of the membrane is similar to vascular disease seen in diabetic patients," the scientist added.