Thursday , October 21 2021

The LSMU scientists have achieved a breakthrough in the treatment of the most aggressive forms of brain cancer



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"If all parts of the project succeed, as we have planned, we will have tools that can greatly improve the predictions of this disease," said Dr. LSMU MA Neuroscience Institute. Aistė Jekabsone. According to scientists, the effectiveness of the main method will be clear after clinical trials, which will show if the foundation for new therapies is successful.

Current treatments are not effective

Gliomas – the most common form of brain tumor. The worst forms of glioblastoma – treatment is complicated today and the survival time is very short. "Glioblastoma grows very fast, has the ability to regenerate, suppresses the immune system and has a large invasion of healthy tissue," said Dr. Neuroscience, Head of the Molecular Neuronology Laboratory, Neuroscience Institute. Kęstutis Skauminas. According to the doctor, the shape of the tumor is complicated due to the fact that healthy brain tissue usually spreads and therefore all tumors cannot be removed.

The most commonly used treatment methods are radiotherapy or chemotherapy, as well as clinical trials with other newer therapies, immunotherapy and bone marrow therapy. "At present, glioblastoma has a moderate survival time of 12-18 months, according to various clinics, because the current treatment method cannot completely destroy tumor cells and prevent the disease from becoming more active," Dr. Skavainas.

Exogenous prognosis can be changed by exosomal patients. These nanoparticle cells use material and information exchange. A. Jackackson scientists claim that this is like a cellular postal service. "Their information can be very diverse – nucleic acids, proteins. Egozoma-producing cells" label "their membranes with special signals recognized by one cell and the other not. By using natural methods of communicating with cells, we aim to deliver drugs directly to cells cancer passes a healthy one, "said A.Jekabsone.

New technology will replace other forms of cancer treatment

A. Jekabsone believes that the ability to detect and deliver single cancer cells to these drugs is important in treating all oncology diseases. "If the methodology that we develop will work, it will be applicable to other difficult-to-treat cancers," the LSMU scientist said.

According to A. Jekabsone, similar research is being carried out by other countries in the world. However, the development of this technology only took the first step, which is why the biggest inventions are at the forefront. "I think Lithuania can be the first to apply this method to the treatment of glioblastoma," a scientist talked about the prospect of research.

In this unique project there is an interdisciplinary team consisting of LSMU pharmacists, biochemists, doctors, geneticists, anatomical scientists, cell biologists, and even veterinarians. This project has received international recognition. "We are pleased with the maximum number of points to assess the relevance and novelty of foreign experts who value the project," – welcomed Jekabsone.

According to scientists, if the project is successful, it is likely that glioblastoma replacement treatments will be developed.

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