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Mannose sugar can improve cancer treatment

Spain >> Science-Technology

Updated on 11/23/2018 – 10:44

Keywords:cancer, treatment, sugar, mannose, repair

Cancer cells – Archives

London, 11/23/2018 (The People Online) – Some natural supplements, such as sugar mannose, can be very helpful for cancer treatment. According to the results of the study, funded by Cancer Research UK and Worldwide Cancer Research, and published today in "Nature", these nutritional supplements do not only seem to delay tumor growth, but also to increase the effects of chemotherapy on mice of various types. cancer, highlight ABC.

It is known that tumors use more glucose than normal and healthy tissue. However, it is very difficult to control the amount of glucose in your body only with a diet. In this study, researchers found that mannose can interfere with glucose to reduce the number of sugar cancer cells that can be used.

Professor Kevin Ryan, lead author of the Beatson UK Cancer Research Institute, said: "Tumors need a lot of glucose to grow, so limit how much they can use to slow the progression of cancer. The problem is that normal tissue also requires glucose, so we can't eliminate it completely from our body, in our study, we found a mannose dose that can block enough glucose to delay tumor growth in mice, but not so much that normal tissue is affected.This is an initial investigation, but it is hoped to find this perfect balance means that, in the future, Mannose can be given to cancer patients to improve chemotherapy without damaging their overall health. "

Tumors need a lot of glucose to grow, so limiting how much they can use should slow the progression of cancer.

In their study, the researchers first examined how mice responded with cancer of the pancreas, lungs or skin when mannose was added to their drinking water and given as oral treatment. And they observed that adding supplements significantly reduced tumor growth and did not cause side effects.

To test how mannose can affect cancer treatment, mice are treated with cisplatin and doxorubicin, two of the most commonly used drugs in chemotherapy. They see that mannose increases the effects of chemotherapy, reduces tumor growth, reduces tumor size and even increases the life span of some mice.

Likewise, other types of cancer are investigated, such as leukemia, osteosarcoma, ovarian and intestinal cancer. The researchers breed cancer cells in the laboratory and then treat them with mannose to see if their growth is affected.

Some cells respond well to treatment, while others do not. It was also found that the presence of enzymes, which break down mannose in cells, is a good indicator of how effective treatment is.

Mannose is sometimes used for short periods to treat urinary tract infections, but the long-term effects have not been investigated. It is important that more research be done before mannose can be used in patients with cancer.

In this sense, Martin Ledwick of Cancer Research UK, believes that, although these results are very promising for the future of some cancer treatments, "this is a very early investigation and has not been tested in humans. Patients should not prescribe mannose, because there is a real risk effect negative, untested side It is important to consult a doctor before changing your diet drastically or taking a new supplement ».

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