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Genetic reasons why some people don't get drunk after getting drunk

End of year come and toast. But after a few "chins" many of us ended up mourning so much noise.

Sharp headaches, abdominal pain, fatigue and malaise are some of the symptoms that cause motion sickness.

However, that doesn't happen to everyone: some people are fortunate not to suffer the next day if they drink.

In fact, several studies show that up to 25% of those who drink excessively manage to avoid unpleasant consequences.

  • Your months and years lose your life if you drink alcohol every day
  • Why do some people really lose their memory during motion sickness (and what does this say about their health)?

Ava Karuso is one of them. The 25-year-old Australian said that he could go to the bar with his friends, drink with them and be healthy the next day (but not with his friends).

Ava wanted to know how this might be and for that she sent her questions to BBC radio programs "Strange cases of Rutherford and Fry", where scientists Adam Rutherford and Hannah Fry investigated the mysteries of everyday life sent by the public.

"Why do some people suffer so much after one night of drinking, and the others (like me) don't feel any effect at all?" The Australian youth asked.

The brain with a glass of alcohol in front.

Alcohol affects your brain connection.

To find out, Rutherford and Fry started by asking a specialist how alcohol affects our bodies.

"When you drink alcoholic beverages, it takes between 10 and 90 minutes to feel the effects, but in fact alcohol has a very fast effect on your bloodstream," explained Sally Adams, a health psychologist at the University of Bath in England.

"(Alcohol) crosses the blood-brain barrier and basically interacts with all the neurotransmitters in your brain," said the expert, who is one of the few scientists in the world who has devoted himself to studying motion sickness.

Neurotransmitters are molecules that connect our brain and nerve cells, and alcohol affects most of these transmissions.

"This explains why we experience effects that are rare because they cannot speak or go well," Adams said. We also cannot think clearly and usually act impulsively.


But the effects of alcohol on our brains are more related to motion sickness. To better understand the hangover, we must concentrate on other organs: the liver, which processes alcohol.

"When you drink alcohol, your body tries to eliminate it, for that you have an enzyme in the liver called alcohol dehydrogenase," Andrea Sella, from University College London, told the program.

The enzyme removes hydrogen from alcohol and converts it to something called acetaldehyde.

"Acetaldehyde is very toxic," Sella said. Many experts consider it to be the main cause of motion sickness.

Picture of a man drinking alcohol, who reaches his heart

The liver is responsible for removing alcohol from your blood, but not all process it at the same speed.

But if we all process alcohol in this way, why do only some people feel the effects of getting drunk?

Sella explained that it had something to do with the amount of alcohol dehydrogenase enzymes that we have in our hearts.

"The processing speed of alcohol will depend on the amount of alcohol dehydrogenase you have in your system," he explained.

Genetic difference

This factor (the amount of enzymes that metabolize alcohol in your heart) is determined by your genetics.

"Different people have different amounts of alcohol dehydrogenase," Sella explained.

"If you have to remove acetaldehyde, and the levels of these compounds accumulate, you will feel very bad," he said.

This might be the key to answering Ava's question.

Maybe he is genetically better prepared to process alcohol than his friends and that explains his tolerance.

Men with drunkenness or flu look at themselves in the mirror.

Drunk symptoms can be very flu-like.

But there are other possible explanations.

For example, it might have something to do with your immune system.

Inflammatory reaction

"It is still uncertain why people feel so bad during a hangover, but the best theory is that it is an immune response," said Adam Rogers, author of "Evidence: The Science of Alcohol".

Experts see that excess alcohol produces an immune reaction, which causes certain substances to cause inflammation to be released, causing various symptoms.

"If you have had a hangover, you will know it tastes like the flu," Rogers said. "You feel bad, like you're infected."

So you know. If you drink on Christmas and New Year, it's very possible that your heart and immune system will be affected.

Except, of course, you're like Ava.

BBC World<! – Download the attached document from this news ->

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