BioGUNE CIC leads RedHYPOX, the Thematic Network of Excellence Research in Hypoxia which is formed by ten research groups, with similar interests in studies of different mechanisms that mediate responses to hypoxia (oxygen deficit) and their relevance in physiological and pathological situations
BILBAO According to CIC bioGUNE, research into the cellular and molecular basis of the response to hypoxia is a very interesting subject in biomedicine. "The challenge is there and the hopes are very ambitious both from a basic and applied perspective because the fruits of research can represent new opportunities to understand and improve the diagnosis and treatment of diseases that are endemic in our society," Dr. Edurne Berra, Network coordinator and is responsible for the HypoxiPATH CIC bioGUNE group.
For two days, research staff from the Excellence Research Thematic Network in Hypoxia, an initiative funded by the Ministry of Science, Innovation and the University, met in Granada. Experts, international references in their respective fields, in various fields of knowledge, participated in the meeting.
RedHYPOX brings together a variety of experimental approaches ranging from computational approaches to clinical research, through a variety of cellular and animal models, as explained by the research center
RedHYPOX members are included in various institutions that have a "strong track record" in basic research and translation, including several universities (Autonomous University of Madrid, University of Complutense Madrid and University of Seville), hospitals (vall d & # 39; Hebron and Hospital de la Princesa) and research center (CIC bioGUNE, IBiS and IBSAL).
BioGUNE CIC has indicated that oxygen is vital and most cells are "addicted" to oxygen. This is so, that deficits (or hypoxia), even temporary, can have dramatic consequences. Therefore, organisms have engineered mechanisms, at different levels, allowing them to react, adapt and guarantee oxygen homeostasis.
"Hypoxic" episodes occur during embryonic development and in healthy adults, for example, during the height of acclimatization, wound healing or physical exercise. In addition, the use of more or less sophisticated hypoxic equipment to improve sports performance is relatively common.
However, inadequate oxygen supply (due to excess or deficiency) is also associated with diseases such as cancer, metabolism (eg diabetes), inflammation (eg, Crohn's), neurodegenerative (Alzheimer's and Parkinson's) or ischemic disease (for example, stroke and stroke).