Saturday , October 23 2021

Parents praise the landmark peanut study which proves you CAN build tolerance to allergies



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New research has found that it is possible to build tolerance to peanut allergies.

Parents praised the important study, which found that participants usually could not tolerate exposure to even one tenth of an allergen to finally overcome two whole nuts.

Children who suffer from severe allergies take part in a year-long trial, where they are given peanut protein.

Already used to treat pollen, immunotherapy therapy therapy is expected to protect people from life-threatening reactions, reports the Mirror.

Emily Pratt builds tolerance
Emily Pratt builds tolerance

The mother of a six-year-old girl who took part in the trial said it had changed their lives completely & # 39;

Sophie Pratt said: "Before Emily took part, we felt uncomfortable being more than twenty minutes from the hospital and she could not attend the play or party date without me or my husband there.

"We have to constantly study food labels to make sure the beans are completely removed from Emily's diet.

The allergies are so severe that even a small amount of peanuts can cause a very serious reaction. The impact on our family life is very large. "

The 44-year-old woman said at the end of the year-long trial Emily was able to tolerate around seven beans.

The PALISADE study recruited nearly 500 children aged four to 17 years from the US and Europe to take part in the trials of the biggest peanut allergic ever.

Participants were divided into groups that received peanut protein capsules or dummy powder.

The dosage gradually increases every two weeks for a period of six months, before continuing to the "maintenance dose" for the next six months.

The results, published in the New England Journal of Medicine, found that about 67% of children and adolescents can tolerate at least 600mg of peanut protein, compared with only four percent of participants on a dummy placebo.

This study gives hope to parents
This study gives hope to parents

Professor George du Toit, consultant child allergies at Evelina London and chief investigator of the study, said: "Peanut allergies are very difficult to manage for children and their families, because they have to follow a strict nut-free diet.

"Families live in fear of accidental exposure because allergic reactions can be very severe, and can even cause death.

"Until now no one has been offered peanut allergies other than education around peanut avoidance and recognition and self-treatment of allergic reactions."

Peanut allergies, a potentially life-threatening condition, have doubled over the past two decades and affect about 1 in 50 children in the UK.

Allergies are rare and are the most common cause of food allergy deaths.

The PALISADE study was funded by Aimmune Therapeutics, which produced peanut protein used during the trial, and was conducted by researchers from Evelina London Children 's Hospital and King' s College London.

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