Those affected have changed the intestinal flora ¬ę


Researchers have shown that intestinal diseases such as Crohn's disease have "bacterial signs" in their own intestines.

17.01 hours, 21. January 2019

The intestine is sick
The intestine is sick © (c) Adiano Р

Billions of small roommates live in our intestines: communities of bacteria and other microorganisms play an important role in the health of the digestive tract. However, intestinal flora can become unbalanced by taking medication or eating unhealthy. Swiss scientists now have intestinal flora in chronic intestinal disease check and find a typical "signature".

Researchers at the University and Bern Inselspital examined the composition of intestinal flora in patients: For this they evaluated data from 270 people. Crohn's disease, 232 with Ulcerative colitis and of 227 healthy. Partly thanks to the analysis using learning algorithms, they were able to identify "signature" typical of inflammatory bowel disease.

More pathogenic germs

Thus, the patient's intestinal flora is fundamentally different from the healthy. The first had more strains of disease-causing bacteria in the intestine, reports the team around Andrew Macpherson, Bahtiyar Yilmaz and Pascal Juillerat in the journal "Nature Medicine".

In addition, those affected by Crohn's disease or ulcerative colitis less "good" bacteria to find which is very important for intestinal health. These include, for example, bacteria that produce short chain fatty acids and thus strengthen the cells of the intestinal wall and thus protect the protective intestines, writes the University of Bern.

However, two chronic intestinal diseases differ in their "signature", which is the strain of bacteria which is reduced and which is more common. Scientists can also correlate certain compositions of intestinal flora with other disease characteristics, such as disease, that Response to treatment or resurrection intestinal inflammation after a surgical procedure in which parts of the inflamed intestine are removed.

The more we know about pathogenic or beneficial bacteria, the more targets we can activate or suppress them.

Andrew Macpherson, author of the study

The status of the disease during sampling, seems to play a small influence on the bacterial community, as scientists report in a journal article. "The more we know about unhealthy or beneficial bacteria, the more effective we can activate or suppress them to influence disease progression and improve patients' quality of life," Macpherson said.

Intestinal flora can pass Diet, lifestyle and sports activities influence. Researchers from Berne can also confirm the results of the previous study sporty sufferers are associated with less severe disease. More athletic sufferers also find more types of "good" bacteria.


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