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Secretin intestinal hormone activates brown adipose tissue

Secretin intestinal hormone activates energy-consuming brown fat

Researchers have found that the secretion of intestinal hormones that have long been known to have newly discovered additional functions: it activates energy-consuming brown adipose tissue, which causes a feeling of fullness.

Chocolate adipose tissue helps to lose weight

Because brown fat cells consume energy, experts say they may be the key to losing weight and are important for preventing obesity and diabetes. Only a few weeks ago it showed that brown adipose tissue was activated as much food as it was cold. Now, the same team from Munich Technical University (TUM) and Finnish colleagues have explained the physiological mechanism of this activation.

A new study shows that intestinal hormone secretion has an additional function recently discovered: It activates energy-consuming chocolate fat, causing a feeling of fullness. New discoveries can help in fighting obesity. (Picture: Kurhan /

Intestinal hormones are long known

"Strangely, we identified secretin as a key factor," reported study leader Professor Martin Klingenspor of Else Kröner-Fresenius Center for Nutritional Medicine (EKFZ) at TUM in a statement.

Secretin is an intestinal hormone that has long been known. Nutritional medicine has until now assumed that this peptide as a messenger basically fulfills gastrointestinal function.

How to stimulate the secretion of water and bicarbonate from the pancreas immediately after acidified chyme is released from the stomach to the small intestine.

In addition, secretin through the bloodstream as a messenger in the brain to increase satiety. As far as knowledge to date.

Satiety in the brain

The new study, published in the journal "Cell", is now revealed by molecular biology investigation (transcriptome sequencing) that the gene for secretin receptors is also expressed in brown adipose tissue.

"If we stimulate these receptors in brown fat cells with secretin, we can observe direct activation of jitter-free thermogenesis," explained Prof. Klingenspor.

Thermogenesis that is free of crushing is a typical mechanism for the formation of brown heat from heat, but not only consumes energy.

Research reveals that thermogenesis-free shaker is also a prerequisite for fullness in the brain.

The previously accepted teaching was revised

As the message says, there are three possible communication channels from brown fat to the brain:

  1. Increased temperature in the brain,
  2. Neural connections from brown fat to the brain, or
  3. special chocolate fat messenger, called BATOKINE.

Professor Klingenspor considers the formation of heat itself as the most reasonable possibility at this time:

"Thermogenesis in brown fat causes warming of the blood and a slight increase in temperature in the brain; this activates neurons that signal saturation."

The previous assumption is that secretin acts directly on the brain in certain nerve cells, which leads to a feeling of fullness and dampens hunger, revised by these findings.

"Chocolate adipose tissue is interposed, as if, like a relay station," said Prof. Klingenspor.

"The right appetizer can make you faster"

The newly discovered chain of communication between the intestine and the brain begins with the release of secretin during meals, active activation of brown lipid thermogenesis and warming in the brain, which increases satiety.

For example, food-induced thermogenesis in brown fat consumes energy and makes you rich – both important factors in the treatment and prevention of the obesity epidemic in almost all the world.

So will secretine be the right "medicine" in this context? "No," clarified Klingenspor. Chronic pancreatic stimulation will not be good.

However, scientists are looking at ways to naturally stimulate secretin production through certain foods, "the right appetizer can fill you faster and reduce your calorie intake."

Nutrition that will be considered here is the subject of further study. (Ad)

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